Inflammatory skin diseases result from complex events involving dysregulation and abnormal expression of inflammatory mediators or their receptors in skin cells.
Cannabis extract and CBD inhibit mediators of skin inflammation
This study examines the potential effect of an ethanolic extract of Cannabis sativa L. standardized in cannabidiol as an anti-inflammatory agent for the skin, providing a better understanding of the molecular mechanisms of human keratinocytes and fibroblasts.
It was conducted by a team of scientists from the Department of Pharmacological and Biomolecular Sciences at the University of Milan, Italy.
The scientists studied the effects of a cannabis extract and CBD on human skin cells (keratinocytes).
The extract inhibits the release of inflammatory mediators involved in wound healing and inflammatory processes occurring in the skin.
CBD was primarily responsible for the reduced activity of genes involved in wound healing and skin inflammation.
In more technical terms, they summarize the action of the two extracts used :
Cannabis extract and cannabidiol showed different effects on the release of interleukin-8 and vascular endothelial growth factor, both mediators whose genes depend on NF-KB. The effect of cannabidiol on the NF-κB pathway and the release of metalloproteinase-9 (MMP-9) paralleled the effect of the extract, making cannabidiol the major contributor to the observed effect.
The down-regulation of genes involved in wound healing and skin inflammation was at least partly due to the presence of cannabidiol. Our results provide new information on the potential effect of cannabis extracts on inflammatory skin diseases.