Following the increasing number of requests, unscrupulous and especially uninformed salesmen, and the rush to CBD, it is important to set the limits of Cannabidiol, and especially its drug interactions that exist. This article on CBD interactions and uses is one of the bases for the proper use of Cannabidiol.
This article is a collection of all the articles and studies proposed on the subject, for information purposes.
We would like to point out that it is important, for any use of CBD, to be accompanied by your doctor, and to respect intervals of at least 2 hours between any contribution. We deplore the lack of communication by many professionals in the field on this subject.
What is Cannabidiol (CBD)?
Cannabidiol (CBD) is a chemical compound of the cannabis Sativa plant, also known as marijuana. More than 144 chemical compounds, known as cannabinoids, have been identified in the cannabis Sativa plant. While delta-9-tetrahydrocannabinol (THC) is the main active ingredient, cannabidiol (CBD) represents about 40% of cannabis extracts and has been studied for many medical uses.
According to the U.S. Food and Drug Administration (FDA), because cannabidiol has been studied as a new drug, products containing cannabidiol are not defined as dietary supplements. Only the US is affected by this classification.
Users take cannabidiol orally for anxiety, bipolar disorder, a muscular disorder called dystonia, convulsions, multiple sclerosis, Parkinson's disease, schizophrenia…
Cannabidiol is also inhaled to help stop smoking (vaporization or vaporization).
How effective is it?
The Complete Database for Natural Drugs evaluates efficacy based on scientific evidence using the following scale: Effective, probably effective, possibly effective, possibly effective, perhaps ineffective, probably ineffective, ineffective and insufficient evidence for evaluation.
The results of the efficacy of CANNABIDIOL (CBD) according to the only studies validated and registered with the FDA are as follows:
CBD's principle of action
Cannabidiol has antipsychotic effects. The exact cause of these effects is not clear. However, cannabidiol seems to prevent the degradation of a chemical compound in the brain that affects pain, mood, and mental function.
Preventing the degradation of this chemical compound and increasing its levels in the blood seems to reduce the psychotic symptoms associated with conditions such as schizophrenia.
Cannabidiol may also block some of the psychoactive effects of delta-9-tetrahydrocannabinol (THC).
In addition, cannabidiol appears to reduce pain and anxiety.
CBD its interactions and uses
Are there any problems with tolerance?
Cannabidiol is SAFE when taken orally or sprayed under the tongue as appropriate in adults.
Cannabidiol doses of up to 300 mg per day were safely taken orally for up to 6 months.
Higher doses of 1200-1500 mg per day were safely taken orally for up to 4 weeks.
Cannabidiol sprays that are applied under the tongue were used at doses of 2.5 mg for 2 weeks.
Some reported side effects of cannabidiol include dry mouth, hypotension, dizziness, and drowsiness.
- Pregnancy and breast-feeding: There are insufficient reliable information on the safety of cannabidiol intake if you are pregnant or breastfeeding. As a precaution, avoid using it.
- Parkinson's disease: Some preliminary research suggests that taking high doses of cannabidiol may aggravate muscle movements and tremors in people with Parkinson's disease.
Are there any drug interactions?
Yes, but in a moderate way and always at a dependent dose, for the following combinations:
Liver-modified drugs (cytochrome P450 1A1 – CYP1A1- substrates)
Some drugs are modified and degraded by the liver. Cannabidiol may reduce the speed with which the liver breaks down some drugs. In theory, the use of cannabidiol and some drugs that are broken down by the liver could potentiate the effects and side effects of some drugs.
If you are taking medications that are degraded by the liver, talk to your doctor before using CBD. A reduction in the dosage of your treatment may then be necessary.
Below is a non-exhaustive list of some common drugs that are degraded by the liver and that may interact with a significant amount of CBD:
- Protective cancer: flutamide (Eulexin®)
- Colon/colorectal cancer: oxaliplatin (Eloxatin®)
- Non-small cell bronchial cancer: erlotinib (Tarceva®)
- HIV: nelfinavir (Viracept®)
- Anti-rejection: cyclosporine (Neoral®, Sandimmun®)
- Antibiotic: clarithromycin (Zoclar®), erythromycin (Egery®)
- Antipsychotic: amitriptyline (Elavil®, Laroxyl®…), haloperidol (Haldol®, Vesadol®), risperidone (Risperdal®), venlafaxine (Effexor®)
- Anxiolytic: diazepam (Valium®), alprazolam (Xanax®)
- Antidepressant: amitriptyline (Elavil®), paroxetine (Dorexat®)
- Schizophrenia: clozapine (Leponex®, clozapine®)Antiemetic: ondansetron (Zofran®),
- Arterial hypertension : losartan (Cozaar®), propranolol (Hemangiol®, Adrexan®…), verapamil (Isoptine®, Verapamil®), metoprolol (Lopressor®), amlodipine (Amlor®), nifedipine (Adalat®)
- Heart disease: warfarin (Coumadin®).
- Tachycardia: flecainide (Flecain®)
- Anti-cholesterol: lovastatin®
- Diabetes type 2: Glipizide (Glucotrol®)
- Anesthetic: ketamine (Ketamine®)
- Corticosteroid: dexamethasone (Celestene®)
- Sedative: chlormethiazole (Heminevrin®),
- Analgesics: tramadol (Contramal®, Topalgic®, Zulmagic®)
- Anesthetic: methoxyflurane (Penthrox®), halothane (Fluothane®)
- Antiepileptic: valproic acid (Depakine®), phenobarbital (Gardenal®)
- Non-steroidal anti-inflammatory drugs: diclofenac (Cataflam®, Voltaren®), ibuprofen (Advil®, Brufen®), meloxicam (Mobic®) and piroxicam (Feldene®); celecoxib (Celebrex®)
- Anti-fungal: ketoconazole (Ketoderm®), itraconazole (Sporanox®)
- Antihistamine: fexofenadine (Telfast®)
- Hormonal treatment: progesterone (Menaelle®, Utrogestan®), testosterone (Avodart®, Nebido®), progesterone (Estima®, Progestan®)
- Muscles relaxants : Chlorzoxazone (Lorzone®, Parafon®…)
- Bronchodilator/BPCO: theophylline (Dilatrane®, Xanthium®…).
- Alcohol dependence: disulfiram (Esperal®)
- Gastritis reflux: omeprazole (Mopral®, Zoltum®), lansoprazole (Lanzor®, Ogast®), pantoprazole (Eupantol®, Inipomp®).
- Sedative drugs (CNS depressants)
- Cannabidiol can potentiate drowsiness and lethargy in combination with sedative medications.
- Some sedative medications include benzodiazepines, pentobarbital (Nembutal®), phenobarbital (Gardenal®), secobarbital (Seconal®), thiopental (Pentothal®), fentanyl (Duragesic®, Instanyl®), morphine, propofol (Diprivan®) and others…
Are there interactions with natural plants and food supplements?
In combination with certain herbs and dietary supplements with sedative properties, Cannabidiol may cause drowsiness or lethargy. Some of these plants and supplements are listed below:
The score, California poppy, catnip, hops, Jamaican dogwood, kava, L-tryptophan, melatonin, sage, St. John's wort, sassafras, skullcap…
Are there any interactions with food?
There are no known interactions with food.
Insufficient evidence for an evaluation for:
- Bipolar disorder.
Early reports suggest that the daily intake of cannabidiol does not improve manic episodes in people with bipolar disorder.
- A muscle disorder called dystonia.
Early research suggests that taking cannabidiol every day for 6 weeks could improve dystonia by 20% to 50% in some people.
Better research is needed to confirm this.
Some preliminary research suggests that taking cannabidiol every day for up to 18 weeks may reduce seizures in some people. However, other studies show that taking cannabidiol daily for 6 months does not reduce seizures in people with epilepsy. The reasons for the contradictory data are not clear. Maybe the sample size was too small.
Early research shows that taking cannabidiol daily does not improve the symptoms of Huntington's disease.
Early research suggests that taking 160 mg cannabidiol before bedtime improves sleep time in people with insomnia. However, lower doses do not have this effect. Cannabidiol also does not seem to help people fall asleep and may reduce the ability to remember dreams.
Multiple sclerosis (MS).
There is conflicting evidence on the efficacy of cannabidiol for the symptoms of multiple sclerosis. Some preliminary research suggests that spraying cannabidiol under the tongue may improve pain and muscle stiffness in people with MS. However, it does not seem to improve muscle spasms, fatigue, bladder control, mobility, well-being, and quality of life.
Some preliminary research shows that taking cannabidiol daily for 4 weeks improves psychotic symptoms in people with Parkinson's disease and psychosis.
Research on the use of cannabidiol for psychotic symptoms in people with schizophrenia is contradictory. Some initial research suggests that taking cannabidiol four times a day for 4 weeks improves psychotic symptoms and may be as effective as the drug antipsychotic drug amisulpride (Solian). However, other early research suggests that taking cannabidiol for 14 days is not beneficial. Conflicting results may be related to the dose of cannabidiol used and the duration of treatment.
Early research suggests that inhaling cannabidiol with an inhaler for one week could reduce the number of cigarettes smoked by about 40% compared to baseline values.
Social anxiety disorder.
Some previous research shows that taking 300 mg cannabidiol daily does not improve anxiety in people with a social anxiety disorder. However, other early research suggests that taking a higher dose (400-600 mg) may improve the anxiety associated with a public speaking or medical imaging testing in people with SAD.
More evidence will be needed to evaluate the efficacy of cannabidiol for all these uses. The number of scientifically acceptable studies available in humans is limited. However, many (preclinical) experiments and testimonies demonstrate certain effectiveness, but which cannot be scientifically validated for the time being.
What is cannabidiol (CBD)?
Cannabidiol (CBD) is that the primary cannabinoid in industrial hemp (Cannabis sativa L.) In recent years there's increasing interest within the therapeutic potential of CBD, that causes no mind-expanding effects, isn't psychedelic (cannot get you “high”) and even in high doses doesn't cause relevant side-effects.
How will CBD work?
CBD or cannabidiol is that the main active compound in hemp and in contrast to psychoactive drug, it's not psychedelic, thus it doesn’t cause you to high. As you will understand, within the frame there’s the endocannabinoid system, with receptors unfold throughout the brain and body. psychoactive drug activates the CB1 and CB2 receptors, whereas CBD doesn't directly stimulate these receptors.
How will CBD work and what are CBD effects within the body?
CBD doesn't stimulate these 2 receptors; instead, it activates alternative receptors, just like the vanilloid, nucleoside and 5-hydroxytryptamine receptors. By activating the TRPV-1 receptor, for instance, cannabidiol plays a task within the mediation of blood heat, pain perception, and inflammation. Then, CBD inhibits the FAAH protein, a compound that activates the CB1 receptor. By doing thus, CBD minimizes the activation of CB1 by psychoactive drug, reducing its psychedelic effects.
High concentrations of CBD are shown to activate the 5-HT1A 5-hydroxytryptamine receptor, exerting anti-depressant effects. a similar receptor is concerned in a very series of processes from pain perception, appetite, nausea and anxiety to sleep and addiction mechanisms.
CBD blocks CPR55 communication, decreasing bone re-absorption and neoplastic cell proliferation.
CBD blocks the psychedelic action of psychoactive drug, this being one in every of the explanations it’s usually thought of advantageous to mix CBD and psychoactive drug once for treatment functions. However, bear in mind that the positive effects of cannabidiol aren't hooked in to the presence of psychoactive drug, thus you'll be able to still cash in of the health advantages of CBD by buying merchandise that contain solely non-psychoactive CBD.
What is the distinction between CBD and psychoactive drug?
THC (Tetrahydrocannabinol) is psychedelic, whereas CBD (Cannabidiol) isn't. The common effects of psychoactive drug are high spirits, anxiety and STM impairment. CBD decreases all the negative effects psychoactive drug will cause. Another real distinction between psychoactive drug and CBD is that cannabis with elevated amounts of psychoactive drug is generally used for its rest inciting impacts, whereas CBD looks to advance attentiveness.
Does CBD have associate intoxicating effect?
The Cannabinoid psychoactive drug is liable for the intoxicating impact of the hemp plant. A psychoactive drug level of but Chronicles and any dose of CBD are thought of non-psychoactive and so don't have any intoxicating impact. As our merchandise contain but zero.2% of THC, it shouldn't influence your ability to drive a vehicle, however you've got to form the ultimate call, before obtaining behind the wheel.
Do CBD merchandise have healing effects?
We aren't approved to supply health claims. The merchandise offered aren't supposed to diagnose, treat, cure or stop illness. If you've got questions on the medical application and therefore the vary of effects of CBD merchandise, please or raise your doctor or chemist. All statements on this web site ar with none reasonably guarantee of the impact.
Does CBD oil cause facet effects?
Hemp is taken into account usually safe, thus there shouldn't be any vital facet effects of CBD, however we have a tendency to cannot rule them out because it extremely depends on however your body tolerates and adapts to those dietary supplements. we have a tendency to suggest consulting your medico before victimization any dietary supplement, together with our organic CBD oil.
Is CBD legal?
Yes, all our CBD oil merchandise have a psychoactive drug content of but zero.2%, that is considerably under the half of legal limit, so creating it totally legal in European country. The ordinance for legal acquisition is eighteen years.
Can CBD show up in a drug test?
The psychoactive drug concentrations in hemp oil are obscurity close to enough to possess any impact on you: industrial hemp plants (Cannabis sativa L.) usually contain solely a trace quantity of the psychoactive drug that marijuana plants contain. psychoactive drug is that the cannabinoid that's targeted in drug tests. These checks search for the metabolic merchandise of psychoactive drug and start with an easy excrement test sample. The check uses antibodies to discover psychoactive drug and therefore the substance it produces. This check targets the 11-nor-THCCOOH substance and isn't sensitive to alternative cannabinoids together with CBD.
Can you get high from CBD?
No, you won’t get high on CBD because it doesn’t contain high levels of psychoactive drug. Our CBD merchandise contain but zero,2% psychoactive drug and its specifically psychoactive drug (tetrahydrocannabinol) that's psychedelic. CBD is unable to induce you high and is totally non-psychoactive. many folks do feel alleviated and relaxed when taking CBD, however by no suggests that can they feel high or get inebriated.