Nausea can occur from a variety of causes and is far from pleasant. Many chemical and natural solutions exist to relieve or prevent their appearance. A recent study has just been published on the application of 2 cannabinoids against the last ones. Very low doses of THC & CBD are useful against nausea.
Published in early 2020, conducted in the Department of Psychology & Collaborative Neuroscience at the Canadian University of Guelph. You can, as usual, consult it by clicking on this link.
In fact , this study assessed the potential of two strong constituents (THC & CBD) combined in cannabis to reduce nausea. The study was also based on several different objectives:
- Determine effective antinauseant doses of cannabidiol (CBD)
- Determine the efficacy and mechanism of action of combined doses below the threshold of CBD and Δ9-tetrahydrocannabinol (THC)
- Determining effective doses of synthetic cannabidiolic acid (CBDA)
- Determining effective doses of synthetic tetrahydrocannabinolic acid (THCA)
- Determine the mechanism of action of THCA
- Determine the efficacy and mechanism of action of combined subthreshold doses of CBDA and THCA
Results of the application of THC and CBD
The results of the different applications:
CBD (0.5-5 mg / kg,) reduces the conditioned gap induced by LiCl (but 0.1, 20, 40 mg / kg are ineffective). Combined doses below the threshold of CBD (0.1 mg/kg, IP) and THC (0.1 mg/kg, IP) produce suppression of conditioned gap, and this effect is blocked by administration of either WAY 100635 (a serotonin 1A [5-HT1A]) receptor antagonist or SR141716 (SR; a CB1 receptor antagonist). THCA (0.01 mg/kg, i.p.) reduces conditioned spacing and administration of MK886 (a peroxisome proliferator-activated alpha-receptor antagonist [PPARα]) blocked the anti-nausea effect of THCA. Combined doses below the threshold of CBDA (0.00001 mg/kg, i.p.) . And THCA (0.001 mg/kg, i.p.) produce conditioned gap suppression, and this effect blocked by administration of WAY 100635 or MK886.
The authors of the study specify that the combined application of very low doses of CBD and THC (or CBDA and THCA, i.e. their acidic forms) reduces nausea:
In conclusion, combinations of very low doses of CBD + THC or CBDA + THCA strongly reduce the conditioned spacing induced by LiCl. Clinical trials therefore,needed to determine the efficacy of using single or combined cannabinoids as adjunctive therapy with existing antiemetic regimens to manage chemotherapy-induced nausea.