In a study of human cancer cells in the stomach. CBD showed several anticancer effects, including the induction of apoptosis, a mechanism of programmed cell death, by increasing the number of reactive species of oxygen. CBD has anticancer effects on cancer cells in the stomach.
In fact,Cannabidiol (CBD), one of the main composts of hemp, has antitumor properties. We have regularly covered this subject, and you can find many of these studies referring to our blog.
The present study examined the in vitro effects of CBD on human gastric cancer cells.
It was done at the Integrated Chinese and Western Traditional Medicine School, Binzhou Medical University, Yantai, China.
We found that CBD significantly inhibited proliferation and colony formation of SGC-7901 cells.
Further investigations showed that CBD significantly increased gene expression of mutated ataxia-telangiectasia (ATM) and p53 protein genes, as well as negatively regulated p21 protein expression in SGC cells. -7901, which then inhibited the levels of CDK2 and cyclin E, thus leading to the arrest of the cell cycle at the level of G0. -G1 phase.
Besides, CBD significantly increased Bax expression levels, decreased Bcl-2 expression levels and mitochondrial membrane potential, and increased levels of caspase-3 and cut-off caspase-9, thereby inducing apoptosis in SGC-7901 cells.
Finally, the researchers found that intracellular reactive oxygen species (ROS) increased after CBD treatment.
These results indicate that CBD could induce G0-G1 phase cell arrest and apoptosis by increasing ROS production, resulting in the inhibition of SGC-7901 cell proliferation, suggesting that CBD may have effects therapeutics on gastric cancer.