Is the CBD dangerous to humans? The World Health Organization has confirmed that it does not appear to have any potential for abuse or to be harmful to health. A recently published study confirms that large doses of CBD are safe for humans.

Is CBD dangerous?

There is growing interest in the use of purified cannabidiol (CBD) as a treatment for a wide range of conditions because of its anti-inflammatory, anxiolytic, antiemetic, and anticonvulsant properties.

The objective of this study was to assess the hazard of CBD: safety, tolerability, and pharmacokinetics. This was done by administering a single ascending dose of a novel lipid-based oral formulation of Cannabidiol in healthy volunteers after a high-fat meal.

It was published by the Department of Health and Social Services, Office of Cannabis Medicinal, Melbourne, Australia. You can  consult it by clicking on this link.

Up to 20mg of CBD per kilogram of body weight

A total of 24 eligible healthy volunteers (aged 18 to 48 years) were randomized into one of three sequential cohorts (each with six active and two placebo subjects). Cohort 1 received 5 mg/kg CBD or placebo, Cohort 2 received 10 mg/kg CBD or placebo (Cohort 2), and Cohort 3 received 20 mg/kg CBD or placebo. Data on adverse events, vital signs, clinical laboratory evaluations, physical examinations, and concomitant medications were collected to assess safety and tolerability.

CBD was well tolerated in healthy volunteers (mean age: 24.0 years) treated with a single oral dose of CBD. There were no safety concerns with increasing the dose and the safety profiles of CBD-treated subjects and placebo patients were similar. The most frequently reported treatment-related adverse events (TEAEs) were headache (17%) and diarrhea (8%). No serious adverse events (SAEs) were reported.

Following a high-fat meal, CBD was detected in plasma samples 15 minutes after administration. The terminal elimination half-life was approximately 70 hours, suggesting that 2-3 weeks are required to eliminate CBD.

Study Conclusion

This new formulation of CBD demonstrated a favorable safety and tolerability profile in healthy volunteers that were consistent with the profiles reported for other purified CBD products. No serious side effects were observed in this study and there were no safety concerns.

We have already mentioned the positive use of high-fat meals for optimal absorption:

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Study: High CBD doses are safe for humans
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Study: High CBD doses are safe for humans
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Is the CBD dangerous to humans? The World Health Organization has confirmed that it does not appear to have any potential for abuse or to be harmful to health. A recently published study confirms that large doses of CBD are safe for humans.
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CBD.CI
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