CBD (Cannabidiol) is now in use by many people around the world. As with any intake, it is important to ensure that it does not cause dependence, and therefore withdrawal symptoms when stopping. Study: stopping the use of CBD does not cause withdrawal symptoms
The purpose of this study was to evaluate the occurrence of withdrawal symptoms induced by abrupt discontinuation of cannabidiol (CBD) after prolonged administration in healthy volunteers. It conducted by GW Research in Cambridge, UK. It is, of course, available online, by clicking on this link.
30 volunteers selected to receive 750 mg of a highly purified herbal CBD pharmaceutical formulation in oral solution (100 mg/ml; Epidiolex® in the US and Epidyolex® in Europe) twice daily for 4 weeks. Then, in a second phase, they received either 750mg of CBD or a placebo for 2 weeks.
All volunteers completed the cannabis withdrawal scale. Doctors did not notice any signs of withdrawal symptoms in any of the participants.
Twenty-nine participants, or 97% first phase volunteers, reported treatment-related adverse events (AEs) from all causes, such as the most frequently reported diarrhea (63%).
In part 2, 6 (67%) volunteers reported adverse events such as diarrhea and headache. 9 volunteers withdrew due to adverse events in part 1.
In healthy volunteers, no signs of withdrawal syndrome were found with abrupt discontinuation of short-term CBD treatment.