Few studies are available on the bioavailability of cannabinoids as a function of gender or food consumed around the intake. This information is very important for medical professionals using medical cannabis. Recently, Canadian researchers have been able to highlight the increased bioavailability of THC during fat consumption.
This study was made possible thanks to the association of 3 Canadian institutions. Aurora Cannabis, MedReleaf, and the University of Edmonton Faculty of Medicine. You can find it by clicking on this link.
The study was a four-part, single-dose, randomized, double-blind, cross-over study. THC capsules (1 or 2 × 5 mg) to 28 healthy adults (13 women and 15 men) on an empty stomach or after a high-fat meal.
Blood samples collected and parameters determined by non-compartmentalized analysis. Adverse events (AEs), cognitive function (through completion of numerical symbol substitution tests), blood pressure and heart rate also recorded.
The presence of high-fat foods significantly improved the time to peak plasma concentration (T max ) . And the area under the curve (AUC0-24) for THC and 11-OH-THC and reduced the volume of apparent THC distribution (V z / F) and apparent clearance (Cl / F).
So, by using a fat intake (60 g, composed of egg, milk or butter). The presence of THC in the blood concentration increased. For doses of 5mg THC, bioavailability increased by 2.7, and 2 for doses of 10mg THC.
Women had a significantly higher maximum plasma concentration (C max ) than men after 5 mg THC in the fasting state.
No cardiovascular or cognitive effects and only mild effects (drowsiness, fatigue, and euphoric mood) occurred.
These results may help inform guidelines provided by governing health agencies on the effects of cannabis, such as time to onset and duration of action, and assist health practitioners in their prescribing practices. In addition, the doses used in this study are safe to consider for future intervention studies in disease conditions where THC is therapeutically effective.