Many studies on the use of medical cannabis on cancer are now available, but very little on human cases studied scientifically. So,this article highlights a Human Cases on how CBD may improve the effectiveness of chemotherapy and radiation on a brain tumor

The glioblastoma multiforme (GBM) or glioblastoma, also known as astrocytoma grade 4, “is the primary tumor of the brain most common and most aggressive.

Published in January 2019 on Front Oncol magazine, also,this article by the Department of Neuro-oncology, Sirio Libanes Hospital, São Paulo, Brazil. It is available by clicking on this link.

Therefore, the researchers presented 2 cases in which CBD may have improved the effectiveness of chemotherapy and radiotherapy in the case of glioblastoma, a very aggressive brain tumor.

“We describe two patients with a confirmed diagnosis of high-grade glioma (grades III / IV), both with methylated M6-methylguanine-DNA methyltransferase (MGMT) and a mutated isocitrate dehydrogenase (IDH-1) which, after -total, were subjected to chemoradiotherapy and followed by PCV, a treatment regimen based on several drugs (procarbazine, lomustine, and vincristine) associated with cannabidiol (CBD).

Both patients had satisfactory clinical and imaging responses during periodic evaluations.

Immediately following the chemotherapy, one of the patients presented an exacerbated early pseudo progression (PSD) evaluated by magnetic resonance imaging (MRI), which was resolved in a short time.

While, the other patient had a marked remission of the altered areas compared with postoperative MRI scans.

Indeed,such aspects are not commonly seen in patients treated only with conventional modalities.

To sum up,this observation could highlight the potential effect of CBD on increasing PSD or improving chemoradiotherapy reactions that affect survival.

Further investigation with more patients and critical molecular analyses must be performed.

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