The opioid epidemic is due to the abuse of prescription opioid drugs. This study seeks to determine the combination of a cannabinoid with an opioid. that could produce additive or synergistic effects on pain, thus providing greatest analgesia.


In studies involving mice. cannabinoids produce an additive or synergistic effect on analgesia when combined with morphine.

This effect varies according to the intensity of the pain and can be mediative by the CB1 or CB2 receptors.
This study conducted at the Drug Abuse Research Center. Department of Pharmacology, University of Philadelphia, USA.


Morphine in combination with cannabinoids in the formalin test gave synergistic analgesia. Studies with selective antagonists have shown: that cannabinoids act through the CB1 receptor.
Morphine in combination with another cannabinoid in the formalin test was sub additive. In the carrageenan trial, this second cannabinoid synthesized with morphine showed increased analgesia.


Morphine in combination with another cannabinoid in the formalin test was sub additive. In the carrageenan trial, this second cannabinoid synthesized with morphine showed increased analgesia.


These results suggest :

  • The use of cannabinoids will reduce opioids dose under certain pain conditions.
  • The ability of a cannabinoid to produce an additive effect on analgesia .
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