Asthma is a chronic inflammation of the lungs and hypersensitivity of the airways. Asthma remains a major public health problem and, at present, there are no effective interventions to reverse airway remodeling.
Allergic asthma and CBD
In a study on allergic asthma conducted at the Extreme South University of Santa Catarina, in Criciúma, Brazil. And published on 15 January 2019, CBD showed a significant action on mice.
The researchers write:
“Asthma is characterized by chronic inflammation of the lungs and hypersensitivity of the airways. Asthma remains a major public health problem and, at present, there are no effective interventions to reverse airway remodeling. Cannabidiol (CBD) exerts immunomodulatory effects by activating cannabinoid-1 and -2 (CB1 and CB2) receptors located in the central nervous system and immune cells, respectively. However, since the role of CBD in airway remodeling and the mechanisms of CB1 and CB2 are not fully understood, this study aim was for the evaluation of the effects of cannabidiol in this scenario. “
In order to note and quantify the action of CBD, scientists have implemented several techniques to measure this action:
So, allergic asthma induced in mice exposed to ovalbumin, and respiratory mechanics, collagen fiber content in the septa of the respiratory and alveolar tract, cytokine levels and expression of CB1 and CB2 have been determined.
Besides, CB1 and CB2 expressions in induced sputum of asthmatic individuals. And their correlation with airway inflammation and lung function were also under review .
The outcome of CBD's action on allergic asthma
CBD treatment, regardless of dosage, reduces airway hyper-responsiveness.
These results were accompanied by a decrease in collagen fiber content in the septa of the respiratory alveolar tract and the expression of markers associated with inflammation in bronchoalveolar lavage fluid and lung homogenate.
Also,there was a significant and inverse correlation between CB1 levels and lung function in asthmatic patients.
Moreover,CBD treatment decreased the inflammatory and remodeling processes in the allergic asthma model.
The mechanisms of action appear in mediation by CB1 / CB2 signaling, but these receptors may act differently on inflammation and lung remodeling. Thus, CBD, regardless of the dosage, reduced airway hyperreactivity and decreased inflammation.