The use of cannabis for medical and recreational purposes is increasing significantly, but its effects on oral health remain unclear. An American study has just highlighted the positive action of THC on periodontal wounds.
Generally,Periodontitis is an inflammation of the periodontium, i. e. the tissues that support the dental organ: the gum, cementum, alveolar ligament, and alveolar bone.
In fact, the purpose of this study was to study the effects of tetrahydrocannabinol (THC), the main active component of cannabis, on the adherence and migration of fibroblast periodontal cells, to explore its role in periodontal regeneration and wound healing.
It was conducted at the University of Detroit Mercy, School of Dentistry, Detroit, USA. You can find it by clicking on this link.
Basically,the adhesion and migration of human periodontal fibroblast cells (HPLF) were analyzed by an in vitro wound healing test with and without THC. The focal kinase signaling pathway (FAK) was studied to discover the underlying cellular mechanism. Besides,Receptor dependence on cannabinoid effects examined using selective antagonists to block THC.
CBD & periodontitis: the results of the study
The researchers note that:
CB1 and CB2 are both present in periodontal tissues but with different expression profiles. Tetrahydrocannabinol promotes the healing of periodontal wounds by inducing the adhesion and migration of HPLF cells. Due to the activation of FAK (focal adhesion kinase) and its modulation of MAPK activities. The effect of cannabinoids on the adhesion and migration of periodontal fibroblast cells was mainly dependent on CB2.
To simplify, scientists say that THC has improved the healing of periodontal wounds by inducing cell migration and other mechanisms. Also,the CB2 receptor mediated these effects .
In conclusion, these results suggest that cannabinoids could contribute to the development of new therapeutic agents for periodontal regeneration and wound healing.