Cannabinoids are divided into 3 groups: the natural cannabinoids found in the Cannabis plant, the endogenous cannabinoids that are produced by the human body and the synthetic cannabinoids. Of these, some are analogs of natural molecules. Much confusion surrounds the apprehension of these molecules, hence this point needed on synthetic CBD.
Synthetic CBD vs. natural CBD
There is a multitude of molecules that called synthetic CBD: some are simply copies of the natural molecule made in the laboratory, while others are a little different, and others a lot. On the other hand, their molecular structures are similar and act on the endocannabinoid receptors with differences in intensity.
To sum up, the main difference between synthetic CBD and natural CBD is that the first is laboratory creation, without a Cannabis plant ; while the latter is from the plant.
Synthetic molecules and the pharmaceutical industry
As Blin, who supervises the Parkinson’s clinical trial, denotes, with synthetic cannabinoids, the synthetic molecules are the same as the “natural” molecules. They are used for research under a simple supply compared to natural CBD. Moreover,some studies with synthetic cannabidiol have proved effective for these molecules, including one in which synthetic CBD is effective in patients with breast cancer and patients with glioma.
In a review of synthetic analogs of CBD, researchers found that the synthetic molecules tested were effective against inflammation and had antiepileptic properties, such as natural CBD. On the other hand, it turned out that some synthetic CBD molecules showed better pharmacological dynamics: natural CBD only indirectly affects CB1 receptors, while some synthetic analogs (including Abn-CBD, O-1602) bind directly to the receivers for increased effect. It seems that they also stimulate other receptors that natural CBD does not activate.
The synthetic molecules used by the pharmaceutical industry in the research and manufacture of drugs are still mostly in the trial phase, although some drugs containing synthetic cannabinoids already exist. It is important not to confuse them with synthetic cannabinoids that are ” designer drugs ” that are are for leisure use only. So,these kinds of molecules can be extremely dangerous and cause psychotic and cardiac disorders requiring hospitalization.
The products currently available on the market are either products based on natural extracts of hemp or isolated CBD. In addition to the synthetic/natural difference, any traces of pesticides, heavy metals and other pollutants in the choice of product should also be in consideration and organic production should be preferred.
Finally,it is now up to the consumer to ask his distributor about the manufacturing process: which company manufactured the product? where does the CBD come from? Under what conditions was hemp grown? what extraction method used? In the absence of an answer, it is safer not to buy. A company that extracts its own CBD must be able to provide the consumer with the results of the analysis of its samples.