By LeeWEpstein

June 24, 2020


CBD (Cannabidiol) is now used by many people around the world. As with any intake, it is important to ensure that it does not cause dependence, and therefore withdrawal symptoms when it is stopped. Study: stopping CBD use does not cause withdrawal symptoms

Is CBD an addictive drug?

The purpose of this study was to evaluate the occurrence of withdrawal symptoms induced by abrupt discontinuation of cannabidiol (CBD) after prolonged administration in healthy volunteers. It was conducted by GW Research in Cambridge, UK. It is available online by clicking on this link.

30 volunteers were selected to receive 750 mg of a highly purified plant-derived pharmaceutical formulation of CBD in oral solution (100 mg/ml; Epidiolex® in the US) twice daily for 4 weeks. Then, in a second phase, they received either 750mg of CBD or a placebo for 2 weeks.

All volunteers completed the cannabis withdrawal scale. Doctors did not notice any signs of withdrawal symptoms in any of the participants.

Conclusion of the CBD withdrawal study

Twenty-nine participants, 97% of whom were first phase volunteers, reported treatment-related adverse events (AEs) from all causes such as the most frequently reported diarrhea (63%).

In Part 2, 6 (67%) volunteers reported adverse events such as diarrhea and headache. 9 volunteers withdrew due to Part 1 adverse events.

In healthy volunteers, no signs of withdrawal syndrome were found with abrupt discontinuation of short-term CBD treatment.

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