By LeeWEpstein

December 6, 2019

 

Researchers at the University of Guelph in Ontario have discovered how cannabis creates analgesic molecules 30 times more effective than aspirin at reducing inflammation.

The researchers used a combination of biochemistry and genomics to uncover the secrets of marijuana’s success as a drug. They said that their discovery unlocks the potential to create a natural method of pain management that offers powerful relief . And does not carry the risk of addiction associated with traditional pain medications.

Cannabis produces two flavonoids called cannflavin A and cannflavin B, which contain extremely anti-inflammatory properties. They were identified until 1985, but the ban on cannabis prevented research on how the two molecules are actually produced.

When Canada legalized adult cannabis use last year. A team of scientists from the university’s Department of Molecular and Cell Biology undertook to investigate how Sativa biosynthesis can produce flavines . And what cannabis genes are needed to create cannflavines A and B.

Cannabis for pain relief

The team has now solved the mystery and revealed that they come from a non-psychoactive part of the plant. Allowing medical cannabis companies to produce more effective natural health products.

“There is a clear need to develop alternatives for the relief of acute and chronic pain that go beyond opioids”. Said researcher Professor Tariq Akhtar. “These molecules are non-psychoactive and target inflammation at the source, making them ideal analgesics.”

Opioids block brain pain receptors to relieve pain, while cannflavines reduce inflammation to target pain in a more natural way.

Another member of the research team. Professor Steven Rothstein, said the challenge is that cannabis contains extremely low levels of cannflavin A and cannflavin B. This means that it would be impractical to collect huge amounts of cannabis for small amounts of these molecules.

The team is currently working on developing a method for the biological engineering of these molecules so that they can create larger quantities. Toronto-based Anahit International Corp. has obtained a patent from the University of Guelph allowing it to biosynthesize cannflavin A and B outside the cannabis plant and researchers will now try to commercialize this form of marijuana for medical purposes.

Anahit also, plans to create a range of creams, pills, sports drinks, transdermal patches, and “other innovative options” based on cannflavin molecules.

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